Top Definition
A YouTube Best Friend is a common YouTube user that you share interests with ie. Movies, Music, Humor. Your YouTube Best Friend often shares videos with you, puts clever comments on your videos, or sends a friend invite or vice versa. Your YouTube Best Friend and you don't usually know eachothers first names and exclusively "know eachother" through YouTube.
Patrice: Who'd you get a personal message from on YouTube? That's weird.

Dole: Oh it's probably from famguyfan666. We send eachother funny-ass family guy clips.

Patrice: Oh is he like your YouTube Best Friend?

Dole: Totally.
by BBMisawesome March 07, 2010

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