Originates from the mini series The Melancholy of Haruhi-chan Suzumiya. When Kyon and Itsuki try to act like hosts, their behavior drives Mikuru to repeatedly make a high-pitched squeal. Haruhi yells at the two and says that they "made Mikuru cry."
Stranger 2: "Twilight."
Stranger 1: "...... Look what you did. You made Mikuru cry."