look up any word, like pussy:
 
1.
The classiest way to respond to anyone you disagree with.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by illicit_fun_owns September 09, 2009
 
2.
The (obviously) most classy way of politely telling someone that they are wrong. Take it from Joe.
Obama: I like pie.

Joe: YOU LIE!
by jazjaz130 September 11, 2009
 
3.
What Michelangelo shouted at Shredder when Shredder claims that Splinter is dead.
"You lie!"

"Do I?"
by jorgorthebarbarian September 10, 2009
 
4.
The easiest way to object to a statement for which you have no legitimate argument.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by stating the obvious September 13, 2009
 
5.
What Leonardo shouted at Shredder when Shredder claimed that Splinter was dead.
Raphael: Where's Splinter?

Shredder: Ah, the rat. So it has a name. It had a name.

Leonardo: You lie!

Example 2:

jorgorthebarbarian: "You lie!" is what Michaelangelo shouted at Shredder when he claimed that Splinter was dead.

Me: You lie!
by shouldn't have apologized wuss September 27, 2009
 
6.
The douchiest way to respond to anyone you disagree with.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by NightRaven September 12, 2009
 
7.
You lie? Is a short way to say "Are you lying?" or "Are you serious" Basically those. It is used when someone says something absolutely ridiculous and you think they are lying like the example below.
Bre--I'm related to Beyonce!
Jess--NO way!!
Bre--Yup! She's my half aunt!
Jess--You Lie?
Bre--Nope! It's the truth!
by Miss Crayzee May 22, 2009