Short term to say yes sir or yes. It was popularized by Pharrell.
Guy 1: "Wanna get some grub?"

Guy 2: "Yezzer!!"

Guy 1: "Aight man lets go"
by Hitlers_A_Jew February 20, 2009
Slang word used to say yes.

It's just yes and sir combined.
Mostly teens use it these days.
Jonny-Hey man you got the bud?
Jose-Yezzer
by Dulce Maria Part 3 February 12, 2008

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