Variant of "Yeshua" or "Yushke" used in Hebrew- or Yiddish-speaking and other Jewish communities. Sometimes derogatory, "Yeshu" is usually just used by Non-Messianic Jews who just don't know better.
The derogatory use of "Yeshu" is an acronym to refer specifically to the Messianic Jewish (Christian) and historical figure Yeshua in terms of "Yemach shemo uv'zichrono"-- literally, "May his name and memory be wiped out."
yeshu is short for yeah/yes sure.
wanna go somewhere else?