look up any word, like spook:
 
1.
Makes the word yay cooler.
An exclamation of happiness.
You won the lottery? Yayzers!!!
by Kathy Redden January 08, 2004
 
2.
Extreme happiness
Excited for something coming up.
A guy just asked you out your like "Yayzers!"
by CharBear January 26, 2014
 
3.
a slang for the drug cocaine
after i sniffed those yayzers i couldnt feel my face
by gravy train January 22, 2006