It is the parody of the word YOLO. YOWO = You Only Walk Once. They basically make fun of Drake because he was in a wheelchair in Degrassi.
Guy: Lol man I am depressed I hate this wheelchair
Girl: YOWO
Guy:?
Girl: Because you only walk once
Guy:Shut up.
Girl: YOWO
Guy:?
Girl: Because you only walk once
Guy:Shut up.
by abchoneybee March 21, 2012