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It is the parody of the word YOLO. YOWO = You Only Walk Once. They basically make fun of Drake because he was in a wheelchair in Degrassi.
Guy: Lol man I am depressed I hate this wheelchair
Girl: YOWO
Girl: Because you only walk once
Guy:Shut up.
by abchoneybee March 21, 2012
Your Only Weird Once

Its another way of saying Y.O.L.O
Boy: Y.O.L.O

Girl: No , its Y.O.W.O
by HarmonyLovesYou March 09, 2012