Top Definition
You only live once, You only have one penis. That time when you are probably drunk, and there's a hot chick you want to get with, but you know she gets around. Or simply when putting ones penis in jeopardy in sports, or any other dangerous activity that could lead to genital mutilation.
Me: yo tyler, I'm thinking about hitting on Megan over there. I've got a few drinks in me and I've heard she's easy. should I go for it?

Tyler: I don't know man, it's a once in a lifetime opportunity, so YOLO, but remember, YOHOP!

Me: I'm willing to take that risk
by Milano_pablano September 21, 2012

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