Top Definition
A commonly used term among teenagers, similar to YOLO, except more specific to occasions where you have sexual intercourse with random, attractive strangers. It stands for "You Only Get Herpes Once."
Friend One: Dude, that chick is so hot, but she looks like she's a walking STD!

Friend Two: Whatever, YOGHO!
by Kolmipyora August 30, 2012

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