YOAVO - "You're only a virgin once." Basically just like the overused term of YOLO but this is specifically for having sex.
"Dude I'm so going to screw Jenny, YOAVO.
You only a virgin once...
Blonde: I'm pregnant.. But, I'm still a virgin!! :)
Girl: Um... YOAVO.
Blonde: What does that mean?
Girl: You Only A Virgin Once.