Top Definition
n. when an athlete's ego inflates to epic proportions. No project outside of sports is off limits, and the allure of Hollywood only fuels the sickness. The athlete never realizes the ineptitudes of their efforts, because they are so successful in the original sport/area of expertise.
Originates from the Character in the movie Major League, played by Omar Epps and Wesley Snipes. He became to big for his britches and turned to hollywood and endorsements to fulfill his surging ego.
Shaquille O'Neal first became infected with the Willy Mays Hayes Virus upon filming such masterpieces as Kazaam and Steel.
by Nastruthomas February 21, 2010

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