Top Definition
Seriously debilitating illness which affects women. Symptoms as follows...

1. To fail to find a man who can amuse you as much as your Gay Best Friend, therefore obliterating all hope of a totally fulfilling relationship and reducing you to a lifetime of one-night stands and eating ice-cream.

2. To be surrounded by phenomenally irritating, badly-written, one-dimensional characters who are occasionally very, very funny.

3. To do a bad impersonation of Jennifer Aniston in Friends every day of your life.
"Every time I've been out with a man in the last month it's been with my Gay Best Friend. And they were ALL to see The Devil Wears Prada. I think I've got Will & Grace syndrome"
by The Incredibly Orginal Martin February 12, 2007

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