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1.
An extremely large-breasted woman with a penchant for making lesbian jokes in a non-confrontational manner.
"My girlfriend is a riot. She's such a Wickersham."
by BabyGotBack2.0 February 02, 2010
 
2.
The mischievious monkeys in the play Seussical.
The wickershams stole Horton's clover.
by CFuck December 02, 2007