English; derogatory, noun: 1. A woman who, with frequency, has sex with different men; 2. A gay man who, with frequency, has sex with different men; 3. Sometimes used to refer to a prostitute.
This term is never used to refer to friends with loose sexual practices unless in jest, but used almost always towards enemies and strangers fitting one of the 3 above definitions or simply in anger.
Susan is a whore. She fucked two of my brothers and one of my sister's boyfriends and four of his cousins.