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1.
The period of depression following eating at a place like Red Robin, Burger King, Wendy's, etc. and ordering the most expensive burger, Then needing to return to eating single layered burgers and chicken nuggets.

One would most of the time get Whopper Withdrawal 'like a bitch', or 'like mug'.

Note: This seldom happens with Bic Macs, Big Macs usually occur in 'Heart Attack Syndrome' rather than Whopper Withdrawal.
Paul: Hey Jimmy how's it hangin'?
Jimmy: FUCK YOU PAUL!
Paul: What the hell is up with him?
Chris: He had a mushroom and swiss steakhouse burger from Burger King yesterday...
Paul: Whopper Withdrawal?
Chris: Yeah, he's got Whopper Withdrawal like a bitch.
by Nathan Archer January 12, 2009