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1.
Basically "whats the matter with you" slurred into one word with an italian accent.
"Whatsamattayou!"
by Hazard October 23, 2003

Words related to Whatsamattayou

mattayou watsamattau whatamatta whatisamatteryou you alright
 
2.
Saying "What is a matter with you?" in an easy to say catch fraise combining the words "whats" "a" "matter" and "you" to save precious air because we all know that all air will become polluted in a couple years.
Tom- I dont feel so good.

Bob- Whatsamattayou?

Tom- I just told you.
by GRABNAR_69 May 09, 2009