This millennial update of the Swingin' 60's "Whatever turns you on" is a little bit more cynical, yet more open to so-called alternative lifestyles. Truly a "post-porn" phrase, it refers to the internal visualizations one does as fantasy to induce sexual arousal and ultimately, orgasm ("home"). Loosely, it can mean "Whatever makes you happy" or "There's no accounting for taste."
Gossip #1: Have you seen his new wife? She's half his age, and he insisted that she have breast implants done, and that she bleach her hair blonde!"
Gossip #2: Wow. Whatever takes you home, I guess, hmm?
Man #1: I'm painting my house canary yellow... What do you think?
Man #2: Whatever takes you home.