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1.
Phrase used when expressing disbelief or dislike for a given situation. As in, "Why is this happening?"

Born from a third grader's art project. The children were asked to write a story that corresponded with a picture they were given. This particular picture was of a man standing near a flock of birds taking off into flight. The child's story included the phrase, "What's up with those birds?"
Did you hear that we won't be able to use the Arts/Humanities Bridge for the next six months? What's up with those birds?
by Lindsay Katai February 15, 2005