Top Definition
It's basically a more boastful way of asking "Whats up?", it's like asking how someone is doing and saying you're in a good mood at the same time.

Popularized by Method Man in the N.A.S.A song "NASA Music" with E-40, another originator of slang.
Bobby: You man how are you doing?
Joey: Hey what's upper??!
Bobby: Damn why are you in such a good mood?
by Dexter Von Doom February 11, 2009

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What's popping my nigga? E-feezy style
What's uppers bitch, i'm a skeet all up on you
by CH, CH ,CH, CHIMP UNIT!! May 07, 2005

The Urban Dictionary Mug

Lotsa space for your liquids.

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The Urban Dictionary Mug

Lotsa space for your liquids.

Buy the mug

The Urban Dictionary Mug

Your favorite word on a white mug.

Create a mug

The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

Buy the mug

The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

Buy the t-shirt

The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt