Used to suggest a problem in another's mental state. This is a response to an unprovoked statement or inappropriate action. Can also be used in third person.
"What's up Eric?"
"Fuck off Gil, next time I see you I'm gonna beat your ass and give you an Abe Lincoln"
"What's your problem man?"

(Gina finds her brother masturbating on her bed in the nude)
"You couldn't walk down the hall to do that Phil?!?! What's your problem?!?!?"

"Yo Jennifer always flips out every time I try space docking"
"What's her problem?"
by tripleski6 June 14, 2011

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