You would expect to find the Snobbleys and Bickersons residing in West Bubblefuck, whereas you'd expect the inhabitants of BFE to be mostly TPT and cornpone.
In either case, the location refers to some place "way out to hell and gone".
"My cousin's family, quite pedigreed you know, want to move from their comfy townhouse in the suburbs out to that new development in south county. They're looking at buying some kind of barn-converted-loft, for God sakes, with acreage. That's like moving from West Bubblefuck out to Bumfuck Egypt if you ask me. So retrograde. Why don't they move into the city, where there's some culture?"
"If it ain't nothing like my hood...it's West Bubble Fuck."