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1.
(n). A state of mind one has when he/she wakes up the morning after night of drinking and realizes with regret, some of the things they have done or said the night previous.

A deep feeling of shame and regret, brought on by binge drinking and hormones.

A pun on the use of famous hockey player, Wayne Gretzky's name.
Friend: What's up? How was last night?

Friend 2: Ughh.. Don't ask. I have a major case of the Wayne Regretzkys.
by Puss&Boots January 04, 2014