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1.
To be beaten by a computer at a game.
All Time Jeopardy Champion Ken J. was Watsoned last night on Jeopardy.
by mpWannaBe March 03, 2011
5 1
 
2.
V. To have been unexpectedly extremely drunk.
Derivation. From two friends who, though unrelated, shared the same house, surname and a propensity for beer and other intoxicating substances. Friends and associates who tried to keep up with their consumption would inevitably suffer the following day.

Can only be properly used in the past tense.
Boss. Radegast, you look rough this morning!

Hungover. Yeah, I got Watsoned last night!

Boss. Ah! Nuff Said.
by Peter Radegast June 12, 2003
8 5