Originally thought to be a women who was cursed by an ancient Cherokee priest for interrupting a male rite of passage, turning her into a half women half panther creature. Now the modern definition is a normally respectable, likeable, and often pretty girl, who when drunk goes on the prowl for any boy she can get a hold of. Should be avoided, can lead to awkward Sundays and lots of vomit.
Dude, she just tried to make out with me on the dance floor for the fourth time.
Yeah she's a wampus cat dude, watch out.