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1.
To have power, money, talent, fame, and everything that goes with it. Then destroying it by medically changing your sex via a mixture of hormones, drugs, and surgery.
“I just made one of the greatest science fiction movies of all time. I think I’ll do a wachowski and chop my manhood off to become a woman.“
by Adrian Toomas August 09, 2006
 
2.
The act of churning out crap because you once made or did something so cool that you know you don't even have to try anymore. Usually to the detriment of the original work or deed.
verb: Star Wars was awesome, but George Lucas totally Wachowski'd the prequels.
by Enphyniti August 01, 2011