look up any word, like dirty sanchez:
 
1.
the literal meaning is what the fuck is up. it can be used as a question, greeting, or interjection.
Ana:(to friend) Hey look its that hottie kyle
Kyle:(to me) Its that bitch ana again
Ana: hey kyle, how have you been?!
Kyle: WTFIU!
by Chode Trickery April 15, 2011