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1.
Venereal Trifecta: noun;
1.) Refers to 3 random venereal diseases obtained from the same sexual partner (typically female) during the same encounter.

2.) May also refer to the condition (usually negative) of one's genitalia.
Def 1: Man, stay away from Mary, I fucked that skanky petri-dish with legs last week and got the Venereal Trifecta; Chlamydia, Syphilis and the HIV!

Def 2: Did you see her cunt? Total Venereal Trifecta; Foul smelling, hairy and meat curtains! That bitch is so skanky that the crabs in her pussy are hanging themselves from the string on her tampon!
by arrogantfu(k June 18, 2010