Also known as "VD" (commonly mistaken with venereal disease), Vegas Depression comes about about a month or less after coming home from a trip to Las Vegas. It will hit you out of the blue and it is hard to get rid of. A common symptom of VD is going onto Expedia.com or priceline.com to look at prices of trips. The only cure* to Vegas Depression is to go back to Vegas. VD is something you cannot get rid of no matter how many times you go.
*cure- meaning not so much of a cure but something to help the pain (only while you are in Vegas)
Tommy: "Yo, I have VD really bad!"
Will: "What the fuck, that's sick!"
Tommy: "No, I have Vegas depression. I was sitting at my shitty job today and it just hit me out of the blue."
Will: "Shit, I'm depressed now."
Tommy: "Oh well, I guess we can check prices on Expedia."