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1.
Uy
An exclamation of surprise, fear, or disgust (see eww ick). Predominantly used by Latinos, especially Caribbean Latinos. Can also be used to replace the word weird. Pronounced "oo-ee". Sounds similar to the Australian oi or Jewish oy, but with a "u" sound rather than an "o" sound.
(e.g. #1) "Oh my God, Carlos, you have 12 toes! Uy!"

(e.g. #2) "Uy, roaches freak me out!"

(e.g. #3) "You expect me to go on that roller coaster? Uy, no! You must be outta your mind!"
by Burina June 30, 2006
 
2.
Uy
Adjective (oo-ee)

Somebody that does something annoying and makes u hate them for no apparent reason. Such as a weird face or a particular catch phrase. Some people might think the "wazzzaaaa" thing from scary movie is "uy."
"I hate when that lady comes in, she always does something uy."
by Chingon December 15, 2005