Top Definition
When someone is rather unattractive before a weight loss, face altercation ( example, nose job, jaw realigning,etc...) was not full of themselves before the transformation, but after becoming so called "hot" or attractive and becomes a major bitch and having major changes in personality, etc.. super judgemental to other.
"Heidi totally got a case of "Ugly-Hot Girl Syndrome" when she got her face done. She is a total bitch now and completely full of herself."
by Trex2344 May 07, 2010

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