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1.
When an individual posesses a rather unorthadox gene in ones DNA causing unorthadox actions and manerisms at random intervals.

The U-gene was first discovered in one Nimesh Jani a.k.a Lippifool
Person 1: (shakes head and make unorthadox sounds)

Person 2: YO! your a Ugene!
by annomous December 15, 2007