UYB = Use Your Brain.
usually use for telling friends or jokes.
Acronym: Up Your Bum/Butt is a safer alternative to femoral injecting for drug users.
While UYB is a safer alternative for injectors it carries greater risks than other non-injecting ways of taking drugs such as smoking, swallowing, or snorting.
Drugs taken UYB have a faster and fuller effect than when smoked.
My groin is pinned to shit, gonna have to go UYB.