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1. UYB
UYB = Use Your Brain.
usually use for telling friends or jokes.
UYB, badass!!
2. UYB
Acronym: Up Your Bum/Butt is a safer alternative to femoral injecting for drug users.

While UYB is a safer alternative for injectors it carries greater risks than other non-injecting ways of taking drugs such as smoking, swallowing, or snorting.

Drugs taken UYB have a faster and fuller effect than when smoked.
My groin is pinned to shit, gonna have to go UYB.
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