Top definition
To smack down, to destroy, to annihilate. Up in your face, in your grill.

A group of online gamers that play on all gaming systems.
Player 1: Have you guys played against anyone who has UPnU in their tag?

Player 2: No.

Player 1: Man they kicked our ass last night.
by liquidfuse January 22, 2011
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2
ur so upnus
by robyn September 20, 2003
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Soft and offensive. Just like you.

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