Top definition
When a number of things are irritating or causing you problems at once. The reference comes from describing a porn scene where a girl took double anal from a group of guys. Someone said, "She was having a Tylenol Weekend."
Bob can't find his keys, wallet, and he is running late for work - he must be having a Tylenol Weekend.
by Doc Irysch July 31, 2009
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Cleveland Steamer Plush

The vengeful act of crapping on a lover's chest while they sleep.

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