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1.
Homosexual
"Man, that guy is two dudes."
by kidjones November 04, 2003
 
2.
Two dudes are causing a nationwide crime wave. Whenever an assault victim is brought into the ER and the cops show up to take the crime report, the alledged perps are always 'two dudes" and the victim was always just "minding my business" If only we could incarcerate these nefarious "two dudes" crime rates would fall drastically and more people would be free to "mind their own business"
I was just minding my own business when these two dudes put a cap in me
by sgrant39 April 28, 2011
 
3.
verb.

When something is going really, really well, then all of a sudden the whole situation gets totally fucked. Literal translation/origin: Girl sends Guy a booty call text message at 2am, but when Guy shows up, there's two dudes just chillin on the couch with Girl. As such, the guy got "two-dudesed."

Similar to cock block or buzzkill.

Can also be used to imply "fucking shit up."

"Two Dudes" may also be used as a noun referring to a person who constantly ruins kickass situations.
(v.) I was mackin on this chick last night and it was going great until her fat friend showed up and totally two-dudesed me!

(v.) That party was totally awesome until the cops showed up and two-dudesed the whole evening.

(v.) If that guy says one more word to me I'm fully going to go two-dudes on him.

(n.) Tommy is such a tool. He's pretty much a two-dudes.
by Jonah Sauce July 16, 2008
 
4.
Characters created by mrandmrswheatley.co.uk (see also b3ta). Probably appearing in a margarine advert very soon.
Dude 1: "Dude, you are sooooo gay"
Dude 2: "I think you'll find you're gay"
Dude 1 "I'm sorry, did you say you were gay?"
by Marc GJ June 22, 2004