When something is going really, really well, then all of a sudden the whole situation gets totally fucked. Literal translation/origin: Girl sends Guy a booty call text message at 2am, but when Guy shows up, there's two dudes just chillin on the couch with Girl. As such, the guy got "two-dudesed."
Similar to cock block or buzzkill.
Can also be used to imply "fucking shit up."
"Two Dudes" may also be used as a noun referring to a person who constantly ruins kickass situations.
(v.) That party was totally awesome until the cops showed up and two-dudesed the whole evening.
(v.) If that guy says one more word to me I'm fully going to go two-dudes on him.
(n.) Tommy is such a tool. He's pretty much a two-dudes.