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1.
a condition where one is unable to think of something to tweet about

a state of sluggishness or inactivity
"Oh man, I don't know what to tweet about! I must have twitterpation."

See constipation
by Unicornasaurus April 14, 2010
 
2.
The state of being entirely infatuated with someone
They've been together a while. It looks like they're in pure twitterpation.
by gingrich April 09, 2008