1. A girl that's down for a good time;and will do whatever with whoever.
2. A girl that dont give a damn about what she does sexually.
1. They just ran a train on that twirley.
2. Invite Breaunna & Brittney over them bitches are twirley's
by Kyerstin November 14, 2005
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When someone is tryin to keep all the hoes to themselves or cockblockin
Ay o bro..why you be cuffin the twirleys i was bout to get on
by dreadrea December 12, 2009
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