Top Definition
Based off of Metal Gear Solid, The Twin Snakes Syndrome is when there are two people (Male or female) who are usually friends, or siblings, or in any case extremely similar, yet almost exactly opposites. (It's also better if they look like Liquid Snake and Solid Snake)
Hey have you seen Carl and Andrew?

Yeah, they seem like good friends, but they fight a lot....

Totally Twin Snakes Syndrome.
by TheOtherSnake January 18, 2012

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