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4.
Basically a meet-up, but for cunts.
ass1:
@ass2 hey, u going to the DC tweet-up?

ass2:
@ass1 yeah boyyee!
by Rohaq March 12, 2009
 
1.
An organized or impromptu gathering of people that use Twitter. (A meet up of people that 'tweet' using Twitter.)
Are you going to the "tweetup" tonight?
by @stephenpc November 09, 2008
 
2.
A gathering of nerds attempting social contact, likely for the first time. Usually disintegrates into everyone running to the nearest computer to type to one another.
Tommy: Hey Jethro, quit playing WoW its time to meet some folks at the tweetup!

Jethro: Oh yeah I forgot about that, I can't wait to meet BigBootay421 at the tweetup, but first I need to slay this orc!
by SteveBonus August 05, 2009
 
3.
Taking social media one step further and meeting the people from twitter, as a group, that you socialize with on a daily basis.
him: Did you hear about that tweetup in Canada?

her: You mean #tweetONeh? I was there! It was the best tweetup ever!
by tweetup attendee June 24, 2013
 
5.
A group of friends on Twitter (social network) that are planning to meet up. A request by a user to meet with friends via Twitter.
Hey @user1 and @user2, u guys wanna tweetup at the Nickelback concert at Mariner?
by Blaede January 19, 2009