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2.
That girl at work who sits on twitter all day not working while you slave away for the man.
I can't believe Krystal twittered that I spilled ketchup on my pants at lunch? What a tweetho!
by cantalop March 04, 2009
 
1.
A real female name derived from Garden Grove, CA.

There only exists one person with this name and she just so happens to be the sexiest Asian persuasion in the world.
Have you seen that girl Tweet Ho, she's the only Tweet Ho in the world.
by AAMH January 06, 2013