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1.
When a girls pussy lips are so loose they get knoted together with the thong
When i was walking in school i felt an extreme amount of pain in my twat and i looked and i had a huge twat knot
by Fin Germatwat October 31, 2010
 
2.
a chick's clit.
that girl has a huge twat knot.
by jcal123456789 September 24, 2008
 
3.
A person that does not return your calls, text messages etc. in a timely manner.

Q. Did she call you back?
A. No, she is such a Twat knot!
by Squish79 July 27, 2008
 
4.
Insult. Origin unknown.
"Don't get your twat in a knot, you twatknot!"
by Alistair_123 October 01, 2005