Top Definition
A well-known phenomenon among Esctasy users. If you spend your weekend rolling, chances are your serotonin will bottom out on Tuesday, leaving you with a depression that could be anywhere from mild to severe. May only last the day, or may stretch out over the rest of the week, depending on the person.
Rob took a few pills on Saturday night, and he's looking a little listless today - must be the Tuesday blues.
by Millsie February 02, 2007

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