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Try.soh.mee (noun)

1. An act that expresses complete retardation. Derived from the condition "Trisomy 21" (Down's Syndrome)

2. Complete idiocy (see retarded)
Example 1
Person A: Hey, did you see what Fred did last week?
Person B: Yeah, that was some Trisomy right there.

Example 2
Person A: I'm a sneaky butterfly that rides on colorful unicorns, yay!
Person B: Trisomy, much?
by SqeakyDurrie February 28, 2011
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2
Name given to one exhibiting qualities characteristic of one suffering from the genetic disorder Trisomy-21(Down's Syndrome). A retard, or, if the person has only been tarded once, a tard. Also, one who is especially ugly and/or shows extreme signs of stupidity.
"Man, Trisomy is one ugly dude. He's not too bright either. He looks like he gets punched in the face every morning after eating a bowl of Frosted Stupid-O's."
by Whodat11 February 26, 2006
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