An irrational negative response to transgender and intersex people, as well as other forms of gender-bending and gender non-conformity. Extreme cases may involve the belief that people with the above conditions are less than human. Often carries that assumption that gender is a natural, rather than learned, condition, and that biological sex is a discrete, immutable trait rather than a collection of characteristics. Related to homophobia.
A trans lady was attacked by a dude with an intense case of transphobia, who claimed that she was really a man and should have expected to be attacked since 'he' was wearing a dress. The newspaper that reported the attack was also transphobic, as they described the lady using her birth name and male pronouns, even though her name and sex have both been legally changed.
The transphobia permeating the media is a contributing factor to the 47% suicide rate among transgender youth.