1. Any problems caused by trannies.
2. When someone causes problems with a tranny.
3. A fight between two trannies.
4. When a sex change operation goes wrong.
5. Any trouble involving a tranny.
Joe: Did you see that movie with that guy who married what he thought was a woman, but it was actually a man and then he killed himself like ten years later when he found out?
Me: Nah, but how did he not know? Did the tranny have a trangina?
Joe: I don't think so.
Me: That sounds like some tranny trouble right there!