An excellent podcast put on by Luke Burbank, Jen Andrews, and Sean DeTore. The podcast stems from a radio show by the same name (often abbreviated "TBTL") that was cancelled on September 11, 2009.
Based in Seattle, Washington, it is often described as the "Seinfeld" of talk radio. Popular segments include Awesome/Not Awesome, This Day in TBTL History, Music for Your Weekend, and Cooking with Sean DeTore.
The show's blog and podcasts can be found at tbtl.net
I was listening to Too Beautiful to Live today and it was freaking hilarious.