The manga series has been published in the Nakayoshi sh¨jo monthly manga magazine in 2001, and has also been collected in the tank¨bon (graphic novel) form, published by Kodansha. An English translation of the manga has been published in North America by TOKYOPOP, and it was published in English in Singapore by Chuang Yi. There is also a sequel series entitled Tokyo Mew Mew ¨¤ la Mode. The anime was licensed in North America by 4Kids Entertainment as Mew Mew Power.
A girl called Ichigo Momomiya and four other girls (Mint Aizawa, Lettuce Midorikawa, Pudding Fong, and Zakuro Fujiwara) have their DNA mysteriously combined with the DNA of endangered animals. Gaining special abilities and a different appearance, they later find out that they have been chosen to protect Earth from the aliens: Kish, Tart, Pie, and the mysterious Deep Blue, who have the power to control aliens which infect animals, turning their hosts into monsters called Chimera Anima (Kirema Anima in the North American manga).
At the same time, these five girls must also work at the Caf¨¦ Mew Mew as waitresses. To make things more dificult for Ichigo, she must also deal with finding out whether her boyfriend, Masaya Aoyama, likes her or knows she is a Mew Mew. She is also pursued by two other boys, Ryou Shirogane, and the alien Kish.