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1.
A girl who has large boobs that are perfectly round.
Guy: Dude! Check out that tits McGhee over there, her boobs are SMOKIN!
by Kylie Hope May 23, 2006
 
2.
1. An amazing woman with many wonderful qualities, all of which are overshadowed by her breasts.

Guy: "Wow, did you see her tits?! Those are incredible"
Girl: "She just found a cure for AIDs and resolved the energy crisis, and all you can focus on are her boobs?"
Guy: "What can I say? She's a real Tits McGhee"
by Tiffany "Titz McGhee" June 20, 2008
 
3.
A girl that has to plan her day around the twins.

Also, spoken of in Anchorman.
I'm Veronica Corningstone, Tits McGhee is on vacation.
by PTM & HFC August 14, 2006