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n. The anxiety or depression that happens when a favorite Doctor on the popular BBC Show: Doctor Who, regenerates into a different actor. This syndrome can lead to a temporary hatred of the Doctor that replaces the old one in said regeneration. Although the the effects can pass quickly, or be prolonged, the victim of TLSA will eventually come around.
"Why did Vanessa seem so sad and was cursing David Tennant's name?
"Oh, she's going through Time Lord Separation Anxiety."
by HCAnimeLover May 29, 2013
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