Top Definition
1. Like the character Ben Stiller played in the movie "There's Something About Mary," the person suffering from this condition still has a strong love for a high school sweatheart, even after years of separation.
2. Like Cameron Diaz's character, this syndrome my also deal with a person stuck between two or more choices of potential partners, in which the person with said syndrome cannot choose who he/she wants.

-can be abbreviated to TSAMS
1. "Hey Brian, I saw Judy for the first time in 7 years"

"Dude, you're suffering from There's Something About Mary Syndrome."

2. "Ugh I can't choose between Brett, George, And Tom"

"Yeah TSAMS really sucks, doesn't it?"
by benny stiler September 07, 2009

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